at Xiamen University for the Sustainable Organic Synthesis

Published Cover Art

32. Illuminating enantioselective alkyl-alkyl coupling 

Zu, W.; Luo, X.; Huo, H.*

Nat. Catal. 2025, 8, 289.

(News & Views)

31. Photo- and Electrochemical Asymmetric Cross-Electrophile Couplings

Xu, Y.; Zu, W.; Huo, H.* 

ChemCatChem 2025, e202500061.

(Invited review)

30. Enantioselective Alkyl-Acyl Radical Cross-Coupling Enabled by Metallaphotoredox Catalysis

Li, T.; Xu, Z.; Huang, Y.; Zu, W.; Huo, H.* 

J. Am. Chem. Soc. 2025, 147, 10999.

(Cover paper)

29. Nickel-Catalyzed, Bromine-Radical-Promoted Enantioselective C(sp³)–H Cross-Couplings

Cheng, B.; Xu, Z.; Huo, H.*

Synlett 2025, 36, 781.

(Invited Synpacts review)

28. Regio- and Enantioselective Hydroacylation of Internal Alkenes with Common Aldehydes

Wan, X.; Huo, H.*

Chin. J. Org. Chem. 2024, 44, 668. 

(invited research Highlight)

27. Enantioselective alkylation of α-amino C(sp³)–H bonds via photoredox and nickel catalysis
Li, J.^#; Cheng, B.^#; Shu, X.; Xu, Z.; Li, C.; Huo, H.*

Nat. Catal. 2024, 7, 889.

(Highlighted in Nat. Catal. 2024, 7, 857; Synfacts 2024, 20, 0929. L.J. and C.B. contributed equally.)

26. Ni/Photoredox-Catalyzed Enantioselective Acylation of α-Bromobenzoates with Aldehydes: A Formal Approach to Aldehyde-Aldehyde Cross-Coupling

Li, C.; Cheng, J.; Wan, X.; Li, J.; Zu, W.; Xu, Y.; Huang, Y.; Huo, H.*

J. Am. Chem. Soc. 2024, 146, 19909.

(Cover paper)

25. Photoredox-Catalyzed C(sp³)–H Difluoroallylation of Amides

Lin, Y.; Shu, X.; Huo, H.*

Synthesis 2024, 56, 1702.

(Cover paper, invited paper for the Special Topic of New Trends in Organic Synthesis from Chinese Chemists.)

24. Metallaphotoredox-Catalyzed Enantioselective Cross-Electrophile Coupling Using Alcohols as Reducing Agents

Li, Z.; Huan, L.; Li, J.; Shu, X.; Zhong, D.; Zhang, W.; Huo, H.*

Angew. Chem. Int. Ed. 2023, e202305889.

(a Top Viewed Article by ACIE in 2023)

23. Site- and enantioselective cross-coupling of saturated N-heterocycles with carboxylic acids by cooperative Ni/photoredox catalysis
Shu, X.; Zhong, D.; Huang, Q.; Huan, L.; Huo, H.* 

Nat. Commun. 2023, 14, 125.

(Highlighted in Synfacts 2023,19, 0371; X.S. and D.Z. contributed equally.)

22. Nucleophilic Radicals as Hydrogen Atom Abstractors in C(sp³)–H Functionalization Reactions
Li, T.; Li, J.; Huo, H.* 

Chin. J. Chem. 2023, 41, 544.

(Invited perspective for the Emerging Topic.)

21. Modular Access to Chiral α-(Hetero)aryl Amines via Ni/Photoredox-Catalyzed Enantioselective Cross-Coupling
Shu, X.;  Zhong, D.;  Lin, Y.; Qin, X.; Huo, H.*

J. Am. Chem. Soc. 2022, 144, 8797.

(Cover paper; one of Most Read JACS Articles in 2022;  highlighted in Synfacts 2022,18, 0953;  X.S. and D.Z. contributed equally.)

20. Photoinduced Nickel-Catalyzed Enantioselective Coupling Reactions
Li, Z.;  Li, C.;  Ding, Y.;  Huo, H.* 

Coord. Chem. Rev. 2022, 460, 214479.

(Invited contribution for the special issue of 100th anniversary of Xiamen University)

19. Stereodivergent Synthesis of Both Z- and E-Alkenes by Photoinduced, Ni-Catalyzed Enantioselective C(sp³)–H Alkenylation
Xu, J.; Li, Z.; Xu, Y.; Shu, X.; Huo, H.* 

ACS Catal. 2021, 11, 13567.

18. Enantioselective β-C(sp³)–H Arylation of Amides via Synergistic Nickel and Photoredox Catalysis
Zhang, W.; Shu, X.; Huan, L.; Cheng, B.; Huo, H.* 

Org. Biomol. Chem. 2021, 19, 9407.

(Invited contribution for the special issue of enantioselective photochemical & photoredox catalysis)

17. Asymmetric Benzylic C(sp³)–H Acylation via Dual Nickel and Photoredox Catalysis
Huan, L.; Shu, X.; Zu, W.; Zhong, D.; Huo, H.* 

Nat. Commun. 2021, 12, 3536.

(Featured in Nature Communications Editors’ Highlights, X.S. and L.H. contributed equally.)

16. Direct Enantioselective C(sp³)–H Acylation for the Synthesis of α-Amino Ketones 
Shu, X.; Huan, L.; Huang, Q.; Huo, H.* 

J. Am. Chem. Soc. 2020, 142, 19058.

(Highlighted in Synfacts 2021,17, 0040; Organic Chemistry Portal; Org. Chem. Highlights 2021, July 12.;  one of Most Read JACS Articles in 2020;  X.S. and L.H. contributed equally.)

15. Catalyst-Controlled Doubly Enantioconvergent Coupling of Racemic Alkyl Nucleophiles and Electrophiles
Huo, H.; Gorsline, B. J.; Fu, G. C.* 

Science 2020, 367, 559.

(Featured in Science 2020, 367, 509)

14. Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex
Huo, H.; Harms, K.; Meggers, E.* 

J. Am. Chem. Soc. 2016, 138, 6936.

13. Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex
Huo, H.; Wang, C.; Harms, K.; Meggers, E.* 

J. Am. Chem. Soc. 2015, 137, 9551.

(Featured in Synfacts 2015, 11, 1071；Synform 2015/12, A172–A174)

12. Asymmetric Photoredox Transition-Metal Catalysis Activated by Visible Light
Huo, H.; Shen, X.; Wang, C.; Zhang, L.; Rose, P.; Chen, L. A.; Harms, K.; Marsch, M.; Hilt, G.; Meggers, E.*

Nature 2014, 515, 100.  

(News & Views Feature by K. Skubi and T. P. Yoon, Nature 2014, 515, 45–46; Synfacts 2015, 11, 0153; Chem. Eng. News 2014, Nov. 10, p. 9; Nachrichten aus der Chemie 2015, 2, 108 and 3, 283)              

11. Asymmetric Catalysis with Substitutionally Labile yet Stereochemically Stable Chiral-at-Metal Iridium(III) Complex
Huo, H.; Fu, C.; Harms, K.; Meggers, E.* 

J. Am. Chem. Soc. 2014, 136, 2990.  

(“ACS Editors’ Choice”, featured in JACS Spotlights and Synfacts 2014, 10, 0487)

10. Cooperative Photoredox and Asymmetric Catalysis
Huo, H.; Meggers, E.* 

Chimia, 2016, 70, 186.

9. Visible-Light-Activated Enantioselective Perfluoroalkylation with a Chiral Iridium Photoredox Catalyst
Huo, H. ; Huang, X. ; Shen, X. ; Harms, K.; Meggers, E.* 

Synlett 2016, 27, 749. 

(H.H. and X.H. contributed equally)

8. Metal-Templated Enantioselective Enamine/H-Bonding Dual Activation Catalysis
Huo, H.; Fu, C.; Wang, C.; Harms, K.; Meggers, E.* 

Chem. Commun. 2014, 50, 10409. 

7. Enantioselective Total Syntheses of (–)-FR901483 and (+)-8-epi-FR901483
Huo, H. H.; Xia, X. E.; Zhang, H. K.; Huang, P. Q.*

J. Org. Chem. 2013, 78, 455.                    

6. A Formal Enantioselective Total Synthesis of FR901483

Huo, H. H.; Zhang, H. K.; Xia, X. E.; Huang, P. Q.* 

Org. Lett. 2012, 14, 4834.

5. Octahedral Chiral-at-Metal Iridium Catalysts: Versatile Chiral Lewis Acids for Asymmetric Conjugate Additions
Shen, X.; Huo, H.; Wang, C.; Zhang, B.; Harms, K.; Meggers, E.* 

Chem. Eur. J. 2015, 21, 9720. 

4. Asymmetric Lewis Acid Catalysis Directed by Octahedral Rhodium Centrochirality

Wang, C.; Chen, L. A.; Huo, H.; Shen, X.; Harms, K.; Gong, L.; Meggers, E.* 

Chem. Sci. 2015, 6, 1094.                  

3. Merger of Visible Light Induced Oxidation and Enantioselective Alkylation with a Chiral Iridium Catalyst

Wang, C.; Zheng, Y.; Huo, H.; Rose, P.; Zhang, L.; Harms, K.; Hilt, G.; Meggers, E.* 

Chem. Eur. J. 2015, 21, 7355.                  

2. Progress on the Total Synthesis of Natural Products in China: From 2006 to 2010
Chen, J.; Wang, A. E.; Huo, H. H.; Huang, P. Q.* 

Sci. China Chem. 2012, 55, 1175.

1. Enantioselective Synthesis of the Diazatricyclic Core of Alkaloid TAN1251C via an Iodoaminocyclization Reaction

Zhang, H. K.; Lin, Z. J.; Huang, H. A.; Huo, H. H.; Huang, Y. J.; Ye, J. L.; Huang, P. Q.* 

Chin. J. Chem. 2010, 28, 1717.